Tissue-Specific Mitochondrial Uncoupling: A Novel Strategy to Enhance Energy Expenditure in Obesity Treatment

  • Focusing on energy expenditure mechanisms to complement current appetite-modulating therapeutic approaches
  • Discovery and characterization of an adipose tissue-enriched small molecule mitochondrial uncoupler that enhances energy expenditure
  • Demonstrating preclinical efficacy and safety by adipose-enriched mitochondrial uncoupling