Timo Müller
Director, Institute for Diabetes and Obesity Helmholtz Zentrum München
Prof. Dr. Timo Müller is a globally recognized expert in metabolic disease research and Director of the Institute for Diabetes and Obesity at Helmholtz Zentrum München. His pioneering work focuses on unravelling the molecular and neural circuits governing energy metabolism, with transformative contributions to obesity and diabetes therapeutics.
Leading an interdisciplinary team, Timo has spearheaded groundbreaking discoveries in GPCR signalling, mitochondrial uncoupling, and thermoregulation. His research has directly informed novel anti-obesity drug development. His lab’s identification of mitochondrial proton leak as a therapeutic target exemplifies his innovative approach to metabolic interventions.
Trained at the University of Cologne and Harvard Medical School, Timo combines deep mechanistic biology with translational acumen, evidenced by his leadership in collaborative initiatives like the German Center for Diabetes Research (DZD). His work has yielded numerous high-impact publications in Nature, Cell Metabolism, and Science Translational Medicine.
Seminars
- Exploring the preclinical delineation of the effects GIP agonism vs. antagonism on food intake and metabolism
- Discovering mechanisms of GLP-1/GIP dual agonism in the brain to accelerate the design of triple-agonists with improved tolerability
- Proposing patient stratification strategies for GIP-targeted therapies to address heterogeneity in response, mitigating trial risks and expanding treatable populations
- Expanding the therapeutic arsenal to target neuronal and metabolic pathways for more effective obesity treatments
- Demonstrating superior fat-loss preservation and GI tolerability in next-gen incretin therapies with brain-specific mechanisms to enable personalised obesity treatment
- Innovating delivery systems from DNA-encoded therapies to oral formulations for sustained peptide delivery
